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Cohort details

Identification
Cohort name: FLEHS
Country: Belgium
Principal investigator: Greet Schoeters (greet.schoeters@vito.be)
Contact for environmental exposures: VMM, IRCEL (Flemish Environmental Monitoring air monitoring institution), OVAM (soil contamination)
Basic information
Source population: Region-based
Describe selection:
Geographical coverage: 8 geographical areas of Flanders
Calendar period: 2002-2004
Enrolment Status: Completed
Developmental period of enrolment:
  • Pre-pregnancy
  • Pregnancy
  • Birth
  • Postnatal
Expected number of participants at enrolment when enrolment completed:
  • Mothers: 1200
  • Fathers: -----
  • Children: 1196
Expected duration of follow-up: Some of them were followed-up for 3y so far: 1) asthma & allergy follow-up: N=200. The children of the asthma& allergy study will be followed-up soon, at the age of 8; 2) neurology study: N=200
Enrolment criteria: - Inclusion: 5 years living in one of the eight areas, able to fill out Dutch questionnaires.
Type of data collection
  Pregnancy Birth Post Natal
  First
trimester
Second
trimester
Third
trimester
  0-6
months
7-18
months
18-60
months
5-10
years
10+
years
Child
Questionnaire Exposures - - - 1200 400 400 350 200 -
Questionnaire Outcomes - - - 1200 400 400 400 1400 -
Cord Blood       1200          
Blood - - - - - - - - -
Urine - - - - - - 400 300 -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Mother
Questionnaire Exposures 1200 1200 1200 1200 - - - - -
Questionnaire Outcomes - - - 1200 - - - - -
Cord Blood       -          
Blood - - - - - - - - -
Urine - - - - - - - - -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - 200 - -
Breast Milk       - - - -    
Other information
Have genetic analysis been performed: yes Year planned:
Details: specific genes
Genes: metabolisation: CYP (1A1,1A2, 1B1, 2E1, 3A4), GSTM1, GSTTP1, GSTT1, NAT2, mEH, MTHFR, COMT; DNA repair: XRCC1, XRCC3, XPD, BRCA2, APEI, OGG1, oxidative stress: mnSOD, CAT, MPO, NQ01, GPX1.
Addresses available:
  • Home: Residential history
  • Mother work: Yes
  • Child school: No
Were these addresses geocoded:
Time activity patterns:
  • Child
    • Questionnaire: No
    • Diary: No
  • Mother
    • Questionnaire: No
    • Diary: No
Sociodemographic variables:
  • Mother's social class: No
  • Father's social class: No
  • Mother's education: Yes
  • Father's education: Yes
  • Mother's ethnic origin: Yes
  • Father's ethnic origin: No
  • Maternal age: Yes
  • Paternal age: No
  • Social class coding system:
  • Household income: Yes
  • Parity: Yes
  • Birth order: Yes
  • Child sex: Yes
Breastfeeding:
  • Weeks of breastfeeding: Yes
  • Weeks of exclusive breastfeeding: Yes
Diet and physical exercise:
  • Dietary assessments: Yes
    • FFQ: Yes
    • 24h recall: No
    • Other dietary assessment: No
    • Child: Yes Timing: 6m and every year (asthma and allergy study N=200)
    • Mother: Yes Timing: after delivery (N=1200)
  • Assessment of physical exercise: No
    • Questionnaire: No
    • Measurement: No
    • Child: No
    • Mother: No
Medical history:
  • Family history: No
  • Pre-Pregnancy medical history: Yes
  • Pregnancy complications:
    • Blood preasure measurements: No
    • Maternal hypertension: Yes
    • Preeclampsia: Yes
  • Maternal allergic history: Yes
  • Maternal pregnancy weight, height: Yes
  • Paternal allergic history: Yes
  • Paternal weight, height: Yes
  • Maternal pre-pregnancy weight, height: Yes
Exposures and Outcomes
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