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Cohort details

Identification
Cohort name: GINIplus
Country: Germany
Principal investigator: Ursula Krämer (kraemeru@uni-duesseldorf.de); Joachim Heinrich (joachim.heinrich@helmholtz-muenchen.de); Dietrich Berdel; C.P. Bauer; S. Koletzko
Contact for environmental exposures: Ursula Krämer (kraemeru@uni-duesseldorf.de); Joachim Heinrich (joachim.heinrich@helmholtz-muenchen.de)
Basic information
Source population: Region-based
Describe selection:
Geographical coverage: Munich, Wesel
Calendar period: 1995-1998
Enrolment Status: Completed
Developmental period of enrolment:
  • Pre-pregnancy
  • Pregnancy
  • Birth
  • Postnatal
Expected number of participants at enrolment when enrolment completed:
  • Mothers: -----
  • Fathers: -----
  • Children: 5991
Expected duration of follow-up: at least 15y
Enrolment criteria: - Inclusion: all healthy newborns were invited to participate
- Inclusion: parents with a healthy newborn and at least one family member with an allergic disease according to the questionnaire.
- Exclusion: severe acquired or congenital diseases
- Exclusion: gestational age of less than 37 weeks
- Exclusion: birth weight of less than 2500 g
- Exclusion: no sufficient knowledge of German language
Type of data collection
  Pregnancy Birth Post Natal
  First
trimester
Second
trimester
Third
trimester
  0-6
months
7-18
months
18-60
months
5-10
years
10+
years
Child
Questionnaire Exposures 5991 - - 5991 - 4671 4354 3878 p
Questionnaire Outcomes - - - 5991 - 4671 4354 3878 p
Cord Blood       -          
Blood - - - - - - X 1962 1802
Urine - - - - - - - - -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Other information
Have genetic analysis been performed: yes Year planned:
Details: specific genes
Genes: FLG, GSTM1, GSTT1, GSTP1 CYP1a1
Addresses available:
  • Home: Residential history
  • Mother work: No
  • Child school: No
Were these addresses geocoded:
Time activity patterns:
  • Child
    • Questionnaire: No
    • Diary: No
  • Mother
    • Questionnaire: No
    • Diary: No
Sociodemographic variables:
  • Mother's social class: No
  • Father's social class: No
  • Mother's education: Yes
  • Father's education: Yes
  • Mother's ethnic origin: Yes
  • Father's ethnic origin: Yes
  • Maternal age: Yes
  • Paternal age: Yes
  • Social class coding system:
  • Household income: Yes
  • Parity: Yes
  • Birth order: Yes
  • Child sex: Yes
Breastfeeding:
  • Weeks of breastfeeding: Yes
  • Weeks of exclusive breastfeeding: Yes
Diet and physical exercise:
  • Dietary assessments: Yes
    • FFQ: Yes
    • 24h recall: No
    • Other dietary assessment: No
    • Child: Yes Timing: 10y
    • Mother: No
  • Assessment of physical exercise: Yes
    • Questionnaire: Yes
    • Measurement: No
    • Child: Yes Timing:10y
    • Mother: No
Medical history:
  • Family history: No
  • Pre-Pregnancy medical history: No
  • Pregnancy complications:
    • Blood preasure measurements: No
    • Maternal hypertension: No
    • Preeclampsia: No
  • Maternal allergic history: Yes
  • Maternal pregnancy weight, height: No
  • Paternal allergic history: Yes
  • Paternal weight, height: Yes
  • Maternal pre-pregnancy weight, height: No
Exposures and Outcomes
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