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Cohort details

Identification
Cohort name: Generation R
Country: Netherlands
Principal investigator: Vincent Jaddoe (v.jaddoe@erasmusmc.ml); Albert Hofman (a.hofman@erasmusmc.nl)
Contact for environmental exposures: Frank Pierik (frank.pierik@tno.nl); Edith van den Hooven (e.vandenhooven@erasmusmc.nl)
Basic information
Source population: Region-based
Describe selection:
Geographical coverage: Predefined area in the city of Rotterdam, the Netherlands
Calendar period: 2001-2006
Enrolment Status: Completed
Developmental period of enrolment:
  • Pre-pregnancy
  • Pregnancy Pregnancy weeks: <18w until birth
  • Birth
  • Postnatal
Expected number of participants at enrolment when enrolment completed:
  • Mothers: 9778
  • Fathers: 6748
  • Children: 9778
Expected duration of follow-up: until adulthood
Enrolment criteria: - Inclusion: delivery date from April 2002 until January 2006
- Inclusion: resident in the study area at their delivery date
- Inclusion: enrolment in pregnancy or at birth of their child
Type of data collection
  Pregnancy Birth Post Natal
  First
trimester
Second
trimester
Third
trimester
  0-6
months
7-18
months
18-60
months
5-10
years
10+
years
Child
Questionnaire Exposures - - - - - - - - -
Questionnaire Outcomes X X X 9745 5202 5322 o o -
Cord Blood       5857          
Blood - - - - - - - X -
Urine - - - - - - - X -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - o o -
Breast Milk       - - - -    
Father
Questionnaire Exposures - 5177 - - - - - - -
Questionnaire Outcomes - - - - - - - - -
Cord Blood       -          
Blood - 5326 - - - - - - -
Urine - - - - - - - - -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Mother
Questionnaire Exposures 6748 8605 8880 9778 - - - - -
Questionnaire Outcomes 8880 8880 8880 8880 - - - - -
Cord Blood       -          
Blood 6398 7616 229 - - - - - -
Urine 2348 3231 3667 - - - - - -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Other information
Have genetic analysis been performed: yes Year planned:
Details: specific genes
Genes: GWAS and specific genes: SNPs
Addresses available:
  • Home: Residential history
  • Mother work: No
  • Child school: Yes
Were these addresses geocoded:
Time activity patterns:
  • Child
    • Questionnaire: Yes When: various ages
    • Diary: No
  • Mother
    • Questionnaire: No
    • Diary: No
Sociodemographic variables:
  • Mother's social class: Yes
  • Father's social class: Yes
  • Mother's education: Yes
  • Father's education: Yes
  • Mother's ethnic origin: Yes
  • Father's ethnic origin: Yes
  • Maternal age: Yes
  • Paternal age: Yes
  • Social class coding system: Statistics Netherlands
  • Household income: Yes
  • Parity: Yes
  • Birth order: Yes
  • Child sex: Yes
Breastfeeding:
  • Weeks of breastfeeding: Yes
  • Weeks of exclusive breastfeeding: Yes
Diet and physical exercise:
  • Dietary assessments: Yes
    • FFQ: Yes
    • 24h recall: No
    • Other dietary assessment: No
    • Child: Yes Timing: 1y
    • Mother: Yes Timing: 2nd trimester of pregnancy
  • Assessment of physical exercise: Yes
    • Questionnaire: Yes
    • Measurement: Yes
    • Child: Yes Timing:accelerometers: 2 years (N=1000); Questionnaire: at 5 years
    • Mother: No
Medical history:
  • Family history: Yes
  • Pre-Pregnancy medical history: Yes
  • Pregnancy complications:
    • Blood preasure measurements: Yes
    • Maternal hypertension: Yes
    • Preeclampsia: Yes
  • Maternal allergic history: Yes
  • Maternal pregnancy weight, height: Yes
  • Paternal allergic history: Yes
  • Paternal weight, height: Yes
  • Maternal pre-pregnancy weight, height: Yes
Exposures and Outcomes
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