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Cohort details

Identification
Cohort name: Generation XXI
Country: Portugal
Principal investigator: Henrique Barros
Contact for environmental exposures: Henrique Barros; Sofia Correia (scorreia@med.up.pt); Ana Cristina Santos (acsantos@med.up.pt)
Basic information
Source population: Region-based
Describe selection:
Geographical coverage: Porto Metropolitan area
Calendar period: 2005-2006
Enrolment Status: Completed
Developmental period of enrolment:
  • Pre-pregnancy
  • Pregnancy Pregnancy weeks: 1-12w
  • Birth
  • Postnatal
Expected number of participants at enrolment when enrolment completed:
  • Mothers: 8493
  • Fathers: 4351
  • Children: 8647
Expected duration of follow-up: 18y
Enrolment criteria: - Inclusion Main group (enrolled at birth): live newborn, delivered at the 5 public maternity units in Porto Metropolitan area, whose mothers were resident at 6 municipalities in the same region.
- Inclusion sub-cohort (enrolled at pregnancy): pregnant women with gestational age below 13 weeks, who attended their first antenatal visit at 2 of the 5 maternity units referred between 1st December 2004 and 31st December 2005.
Type of data collection
  Pregnancy Birth Post Natal
  First
trimester
Second
trimester
Third
trimester
  0-6
months
7-18
months
18-60
months
5-10
years
10+
years
Child
Questionnaire Exposures - - - - 1690 1040 o - -
Questionnaire Outcomes X X X 8666 1690 1040 o - -
Cord Blood       1822          
Blood - - - - - - o - -
Urine - - - - - - - - -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Father
Questionnaire Exposures - - - 4351 - - - - -
Questionnaire Outcomes - - - 4351 - - - - -
Cord Blood       -          
Blood - - - 633 - - - - -
Urine - - - - - - - - -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Mother
Questionnaire Exposures 349 342 338 8493 - - o - -
Questionnaire Outcomes 349 342 338 8493 - - o - -
Cord Blood       -          
Blood 207 167 125 1842 - - o - -
Urine - - - - - - - - -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Other information
Have genetic analysis been performed: planned Year planned: 2010 and through years
Details:
Genes:
Addresses available:
  • Home: Residential history
  • Mother work: No
  • Child school: No
Were these addresses geocoded:
Time activity patterns:
  • Child
    • Questionnaire: Yes When: 48m
    • Diary: No
  • Mother
    • Questionnaire: Yes When: 1st, 2nd, 3rd trimester (subsample, 300); 48m after delivery
    • Diary: Yes When: 1st, 2nd, 3rd trimester (subsample, 300)
Sociodemographic variables:
  • Mother's social class: No
  • Father's social class: No
  • Mother's education: Yes
  • Father's education: Yes
  • Mother's ethnic origin: Yes
  • Father's ethnic origin: Yes
  • Maternal age: Yes
  • Paternal age: Yes
  • Social class coding system:
  • Household income: Yes
  • Parity: Yes
  • Birth order: Yes
  • Child sex: Yes
Breastfeeding:
  • Weeks of breastfeeding: Yes
  • Weeks of exclusive breastfeeding: Yes
Diet and physical exercise:
  • Dietary assessments: Yes
    • FFQ: Yes
    • 24h recall: No
    • Other dietary assessment: Yes 3 days diary (for the sample of mothers followed during pregnancy); child: 2 days diary (at 2 years and subsample 3000 at 4 years)
    • Child: Yes Timing: 24m, 48m
    • Mother: Yes Timing: during pregnancy for the subsample of 300 mothers; all mothers 48M after delivery.
  • Assessment of physical exercise: Yes
    • Questionnaire: Yes
    • Measurement: No
    • Child: Yes Timing:48m
    • Mother: Yes Timing:during pregnancy for the subsample of 300 mothers; all mothers 48M after delivery.
Medical history:
  • Family history: No
  • Pre-Pregnancy medical history: Yes
  • Pregnancy complications:
    • Blood preasure measurements: No
    • Maternal hypertension: Yes
    • Preeclampsia: Yes
  • Maternal allergic history: Yes
  • Maternal pregnancy weight, height: Yes
  • Paternal allergic history: Yes
  • Paternal weight, height: Yes
  • Maternal pre-pregnancy weight, height: Yes
Exposures and Outcomes
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