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Cohort details

Identification
Cohort name: Krakow cohort
Country: Poland
Principal investigator: Wieslaw Jedrychowski (myjedryc@cyf-kr.edu.pl)
Contact for environmental exposures: Renata Majewska (rmajewska@cm-uj.krakow.pl)
Basic information
Source population: Region-based
Describe selection:
Geographical coverage: Kraków, Poland
Calendar period: 2000-2003
Enrolment Status: Completed
Developmental period of enrolment:
  • Pre-pregnancy
  • Pregnancy Pregnancy weeks: 8-13w
  • Birth
  • Postnatal
Expected number of participants at enrolment when enrolment completed:
  • Mothers: 528
  • Fathers: -----
  • Children: 505
Expected duration of follow-up: 9y
Enrolment criteria: - Inclusion: nonsmoking women
- Inclusion: permanent residents of Krakow
- Inclusion: women who have resided for the past year within a 0.5-km radius of the ambient air monitoring stations with either the highest (the Srodmiescie district) or lowest (the Krowodrza district) PAH levels
- Inclusion: singleton pregnancies
- Inclusion: between the ages of 18 and 35 years
- Inclusion: free from chronic diseases (diabetes and hypertension) and without a history of using illicit drugs or at risk of occupational exposures to PAH or other developmental toxicants (coke oven, chemical or rubber workers)
Type of data collection
  Pregnancy Birth Post Natal
  First
trimester
Second
trimester
Third
trimester
  0-6
months
7-18
months
18-60
months
5-10
years
10+
years
Child
Questionnaire Exposures - - - - 505 496 477 o -
Questionnaire Outcomes - - - 505 505 496 477 o -
Cord Blood       505          
Blood - - - - - - - 260 -
Urine - - - - - - 319 253 -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Father
Questionnaire Exposures - - - - - - - - -
Questionnaire Outcomes - - - - - - - - -
Cord Blood       -          
Blood - - - - - - - - -
Urine - - - - - - - 150 -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Mother
Questionnaire Exposures - 528 505 - - - - - -
Questionnaire Outcomes - - - - - - - - -
Cord Blood       -          
Blood - - - 505 - - - - -
Urine - - - - - - - 173 -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Other information
Have genetic analysis been performed: yes Year planned:
Details: GWAS
Genes:
Addresses available:
  • Home: Residential history
  • Mother work: Yes
  • Child school: No
Were these addresses geocoded:
Time activity patterns:
  • Child
    • Questionnaire: No
    • Diary: No
  • Mother
    • Questionnaire: No
    • Diary: No
Sociodemographic variables:
  • Mother's social class: No
  • Father's social class: No
  • Mother's education: Yes
  • Father's education: Yes
  • Mother's ethnic origin: No
  • Father's ethnic origin: No
  • Maternal age: Yes
  • Paternal age: No
  • Social class coding system:
  • Household income: Yes
  • Parity: Yes
  • Birth order: Yes
  • Child sex: Yes
Breastfeeding:
  • Weeks of breastfeeding: Yes
  • Weeks of exclusive breastfeeding: Yes
Diet and physical exercise:
  • Dietary assessments: Yes
    • FFQ: Yes
    • 24h recall: Yes
    • Other dietary assessment: Yes
    • Child: Yes Timing: FFQ: child’s diet from 3rd to 7th year (all children); 24h: at 3y and 6y; Quest: dietary habits questionnaire (from 6th month to 30th month)
    • Mother: Yes Timing: FFQ: diet before pregnancy; 24h: 1st, 2nd and 3rd T for 100 women and only at 2nd T for 460 women; Quest: dietary habits questionnaire (1st trimester)
  • Assessment of physical exercise: Yes
    • Questionnaire: No
    • Measurement: Yes
    • Child: Yes Timing:9y (ongoing) - 3 consecutive days (when children attend school)
    • Mother: Yes Timing:9y (ongoing) - 3 consecutive days (when children attend school)
Medical history:
  • Family history: No
  • Pre-Pregnancy medical history: No
  • Pregnancy complications:
    • Blood preasure measurements: No
    • Maternal hypertension: Yes
    • Preeclampsia: No
  • Maternal allergic history: Yes
  • Maternal pregnancy weight, height: Yes
  • Paternal allergic history: Yes
  • Paternal weight, height: No
  • Maternal pre-pregnancy weight, height: Yes
Exposures and Outcomes
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