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Cohort details

Identification
Cohort name: LISAplus
Country: Germany
Principal investigator: Joachim Heinrich (joachim.heinrich@helmholtz-muenchen.de)
Contact for environmental exposures: Joachim Heinrich (joachim.heinrich@helmholtz-muenchen.de)
Basic information
Source population: Region-based
Describe selection:
Geographical coverage: Munich, Wesel, Leipzig, Bad Honneff
Calendar period: 1997-1998
Enrolment Status: Completed
Developmental period of enrolment:
  • Pre-pregnancy
  • Pregnancy
  • Birth
  • Postnatal
Expected number of participants at enrolment when enrolment completed:
  • Mothers: -----
  • Fathers:
  • Children: 3097
Expected duration of follow-up: 15y
Enrolment criteria: - Inclusion: both of the parents were born in Germany and having German nationality
- Inclusion: maternity > 37 gestational weeks
- Inclusion: birth weight > 2500 gram
- Inclusion: the child did not have congenital malformation or symptomatic neonatal infection or antibiotic medication
- Inclusion: the child was not hospitalized or admitted to intensive medical care during neonatal period
- Inclusion: the mother did not have any immune-related diseases such as autoimmune disorders, diabetes, hepatitis B, and long-term medication or abuse of drugs and alcohol
Type of data collection
  Pregnancy Birth Post Natal
  First
trimester
Second
trimester
Third
trimester
  0-6
months
7-18
months
18-60
months
5-10
years
10+
years
Child
Questionnaire Exposures 3097 3097 3097 3097 2828 2737 2664 2203 p
Questionnaire Outcomes - - - 3097 2828 2737 2664 2203 p
Cord Blood       3097          
Blood - - - 3097 - - 2664 2203 X
Urine - - - - - - - - -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Father
Questionnaire Exposures - - - - - - - - -
Questionnaire Outcomes - - - 3097 - - - - -
Cord Blood       -          
Blood - - - - - - - - -
Urine - - - - - - - - -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Mother
Questionnaire Exposures 3097 3097 3097 - - - - - -
Questionnaire Outcomes - - - 3097 - - - - -
Cord Blood       -          
Blood - - - - - - - - -
Urine - - - - - - - - -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Exposures and Outcomes
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