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Cohort details

Identification
Cohort name: LUKAS
Country: Finland
Principal investigator: Juha Pekkanen
Contact for environmental exposures: Anne Karvonen(anne.karvonen@thl.fi); Anne Hyvärinen; Hannu Kiviranta (hannu.kiviranta@thl.fi)
Cohort website: N/A
Basic information
Source population: Selected
Describe selection: 25% farmers
Geographical coverage: Four hospitals in the Eastern and Middle Finland (Kuopio, Jyväskylä, Joensuu and Lisalmi)
Calendar period: 2002-2005
Enrolment Status: Completed
Developmental period of enrolment:
  • Pre-pregnancy
  • Pregnancy Pregnancy weeks: 20-34w
  • Birth
  • Postnatal
Expected number of participants at enrolment when enrolment completed:
  • Mothers: 442
  • Fathers: 418
  • Children: 442
Expected duration of follow-up: 6y
Enrolment criteria: - LUKAS1: Inclusion: maternal age 18 years or older; singleton pregnancy; mother tongue Finnish; no plans to move from the study area;
- LUKAS1: Exclusion : delivery before 36 weeks of gestation; congenital abnormalities in the infants; failure to obtain cord blood samples
- LUKAS2: there was no selection by the occupation or area of living; however, subjects living in apartments were excluded to make the building stock comparable between the two parts of the cohort.
- LUKAS3: due to logistic reasons, only women delivering between Sunday afternoons and Thursday mornings were included. Otherwise the inclusion and exclusion criteria were the same as described above. Each mother could take part in the study only once.
Type of data collection
  Pregnancy Birth Post Natal
  First
trimester
Second
trimester
Third
trimester
  0-6
months
7-18
months
18-60
months
5-10
years
10+
years
Child
Questionnaire Exposures - - - - 437 376 376 384 -
Questionnaire Outcomes - - - - - 418 376 380 -
Cord Blood       442          
Blood - - - - - 393 205 385 -
Urine - - - - - - - 380 -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Father
Questionnaire Exposures - - - - 437 418 - - -
Questionnaire Outcomes - - - - - 418 - - -
Cord Blood       -          
Blood - - - - 401 - - - -
Urine - - - - - - - - -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Mother
Questionnaire Exposures 442 442 442 - 437 376 - - -
Questionnaire Outcomes - - - - 437 - - - -
Cord Blood       -          
Blood - - - 418 - - - - -
Urine - - - - - - - - -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - X - -    
Other information
Have genetic analysis been performed: ---
Addresses available:
  • Home: Residential history
  • Mother work: No
  • Child school: No
Were these addresses geocoded:
Time activity patterns:
  • Child
    • Questionnaire: Yes When: 6y
    • Diary: No
  • Mother
    • Questionnaire: No
    • Diary: No
Sociodemographic variables:
  • Mother's social class: No
  • Father's social class: No
  • Mother's education: Yes
  • Father's education: Yes
  • Mother's ethnic origin: Yes
  • Father's ethnic origin: Yes
  • Maternal age: Yes
  • Paternal age: Yes
  • Social class coding system:
  • Household income: No
  • Parity: Yes
  • Birth order: Yes
  • Child sex: Yes
Breastfeeding:
  • Weeks of breastfeeding: Yes
  • Weeks of exclusive breastfeeding: No
Diet and physical exercise:
  • Dietary assessments: Yes
    • FFQ: Yes
    • 24h recall: Yes
    • Other dietary assessment: Yes 3 day food record and diary during 1st year (collected weekly)
    • Child: Yes Timing: 24h recall at the age of 6 years; 3 day food record at the age of 1year; diary during 1st year (collected weekly)
    • Mother: Yes Timing: FFQ during 1 month in the 3rd trimester of pregnancy
  • Assessment of physical exercise: Yes
    • Questionnaire: Yes
    • Measurement: No
    • Child: Yes Timing:6 years
    • Mother: No
Medical history:
  • Family history: Yes
  • Pre-Pregnancy medical history: No
  • Pregnancy complications:
    • Blood preasure measurements: No
    • Maternal hypertension: Yes
    • Preeclampsia: Yes
  • Maternal allergic history: Yes
  • Maternal pregnancy weight, height: Yes
  • Paternal allergic history: Yes
  • Paternal weight, height: Yes
  • Maternal pre-pregnancy weight, height: No
Exposures and Outcomes
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