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Cohort details

Identification
Cohort name: REPRO_PL
Country: Poland
Principal investigator: Wojciech Hanke (wojt@imp.lodz.pl)
Contact for environmental exposures: Kinga Polanska (Kinga@imp.lodz.pl)
Cohort website: http://www.repropl.com
Basic information
Source population: Nation-based
Describe selection:
Geographical coverage: Different regions in Poland: big city (Lodz, Wroclaw), small (Lask, Kielce), polluted (Katowice, Legnica), not polluted (Lublin), north part (Szczecin)
Calendar period: 2007-2011
Enrolment Status: Ongoing
Developmental period of enrolment:
  • Pre-pregnancy
  • Pregnancy Pregnancy weeks: 8-12w
  • Birth
  • Postnatal
Expected number of participants at enrolment when enrolment completed:
  • Mothers: 1300
  • Fathers: -----
  • Children: 1300
Expected duration of follow-up: shortly after delivery in whole cohort and some part the children are followed up to at least 24 months.
Enrolment criteria: - Exclusion: single pregnancy
- Exclusion: up to 12 weeks of pregnancy
- Exclusion: not assisted with reproductive technology
- Exclusion: not expected to be finished as spontaneous abortion
- Exclusion: no serious chronic diseases among mothers specified in study protocol; such us diabetes, hypertension, nephropathy, epilepsy and cancer are excluded from the study. The same is relating to suspicion of serious child malformations.
Type of data collection
  Pregnancy Birth Post Natal
  First
trimester
Second
trimester
Third
trimester
  0-6
months
7-18
months
18-60
months
5-10
years
10+
years
Child
Questionnaire Exposures - - - - - - - - -
Questionnaire Outcomes - - - - - 300 300 - -
Cord Blood       1800          
Blood - - - - - 200 200 - -
Urine - - - - - 300 300 - -
Hair - - - - - - - - -
Nails - - - - - - - - -
Saliva - - - - - - - - -
Breast Milk       - - - -    
Mother
Questionnaire Exposures 1800 1800 1800 1800 - - - - -
Questionnaire Outcomes - - - - - - - - -
Cord Blood       -          
Blood 1800 1800 1800 1800 - - - - -
Urine - 1800 1800 - - - - - -
Hair - - 1800 - - - - - -
Nails - - - - - - - - -
Saliva 1800 1800 1800 - - - - - -
Breast Milk       - 200 - -    
Other information
Have genetic analysis been performed: yes Year planned:
Details: specific genes
Genes: oxidative enzymes (GPX1, GPX4) DNA repair genes (XRCC3, Rad S, Rad S1C); from mother’s blood
Addresses available:
  • Home: Residential history
  • Mother work: No
  • Child school: No
Were these addresses geocoded:
Time activity patterns:
  • Child
    • Questionnaire: No
    • Diary: No
  • Mother
    • Questionnaire: No
    • Diary: No
Sociodemographic variables:
  • Mother's social class: No
  • Father's social class: No
  • Mother's education: Yes
  • Father's education: Yes
  • Mother's ethnic origin: No
  • Father's ethnic origin: No
  • Maternal age: Yes
  • Paternal age: No
  • Social class coding system:
  • Household income: No
  • Parity: Yes
  • Birth order: Yes
  • Child sex: Yes
Breastfeeding:
  • Weeks of breastfeeding: Yes
  • Weeks of exclusive breastfeeding: Yes
Diet and physical exercise:
  • Dietary assessments: Yes
    • FFQ: Yes
    • 24h recall: No
    • Other dietary assessment: No
    • Child: No
    • Mother: Yes Timing: 20-24w of pregnancy
  • Assessment of physical exercise: Yes
    • Questionnaire: Yes
    • Measurement: No
    • Child: No
    • Mother: Yes Timing:8-12w, 20-24w, 30-34w of pregnancy (prospectively)
Medical history:
  • Family history: No
  • Pre-Pregnancy medical history: No
  • Pregnancy complications:
    • Blood preasure measurements: No
    • Maternal hypertension: Yes
    • Preeclampsia: Yes
  • Maternal allergic history: Yes
  • Maternal pregnancy weight, height: Yes
  • Paternal allergic history: Yes
  • Paternal weight, height: No
  • Maternal pre-pregnancy weight, height: Yes
Exposures and Outcomes
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